https://www.ceesdekker.net - An Overview
https://www.ceesdekker.net - An Overview
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Nanotechnology presents An array of opportunities to contribute to biology. Right here I will current examples the place nanofabrication – a chance to make confined buildings with Proportions at will – is made use of to examine the biophysics of one molecules and cells. I'll existing some examples from our lab:
Our team reports bacterial cell division and is aiming to represent a ‘base up biology’ in synthetic cells that can autonomously divide. Our most important fascination lies in cell division, chromatin structure, and spatial Command.
Back again in 1991, Sumio Iijima with the NEC Company experienced described the synthesis of carbon nanotubes. Band composition calculations prompt that these nanotubes could show metallic band conduction. This might be a big edge about the conducting polymers we experienced explored, which have been, the truth is, disordered semiconductors presenting just variable-selection hopping conductivity.
Because 2000, Dekker has shifted the leading focus of his perform to biophysics exactly where he scientific tests the Attributes of single biomolecules and cells using the equipment of nanotechnology. This alteration of area was driven by his fascination to the amazing performing of biological molecular structures, along with because of the extensive-expression point of view that numerous interesting discoveries could be anticipated In this particular subject.[five] Present-day lines of study in his biophysics group are within the regions of:[6]
That could be a desire of mine and we set to work which has a scrumptious dose of naivety. This is certainly something that will probably produce amazing leads to the extended term, but that does not issue. You shouldn't only want to operate within the issues of tomorrow, but also within the inquiries of your day right after tomorrow.’
SMC complexes can go Actual physical roadblocks bigger than their ring sizing, indicating a nontopological system for DNA loop extrusion
Length control of unique carbon nanotubes by nanostructuring While using the scanning tunneling microscope
He also discovered time to jot down a number of textbooks, send Just about forty thousand tweets and lead An effective investigate group at Delft College of Technology. ‘It doesn’t come to feel like work’, he states. ‘I’m just terribly curious.’
2003, shown the primary biosensors ceesdekker manufactured from a carbon nanotube; resolved the composition and system of DNA repair service proteins; and discovery of a different strategy for fabricating sound-state nanopores for DNA translocation
Very amazing, but that wasn’t really in which my fascination lay. I wanted to pioneer and I experienced the sensation that was not probable, because the most exciting essential insights had presently been uncovered. But my subject experienced created a lot of remarkable new resources to measure particular person molecules. I made a decision which i desired to use this to biology, to take a look at it from the Actual physical point of view.’
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A lot of new phenomena had been found out, and he and his investigation group recognized a leading posture In this particular area of exploration. Dekker and his analysis team uncovered new physics of nanotubes as well as explored the feasibility of molecular electronics. In 1998, they ended up the very first to make a transistor depending on only one nanotube molecule.
2005, discovery of your mechanism of DNA uncoiling by topoisomerase enzymes; discovery of extensive-assortment conformational adjustments in Mre11/DNA maintenance complexes; and very first drive measurements on a DNA molecule in a very nanopore
The biophysicist from Delft – who has actually been One of the more cited researchers while in the Netherlands For a long time – will take his responsibility to add to your clarification and popularisation of his perform in the border of physics and biology extremely very seriously and on a regular basis appears within the media; Otherwise to mention his perform, then about the relationship concerning science and his Christian faith.